Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
نویسندگان
چکیده
منابع مشابه
Suprachiasmatic nucleus: cell autonomy and network properties.
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity depends on sufficient membrane depolarization and levels of intracellular calcium and cAMP. In the intact SCN, cellular oscillations are synchronized and...
متن کاملCalcium Circadian Rhythmicity in the Suprachiasmatic Nucleus: Cell Autonomy and Network Modulation
Circadian rhythms of mammalian physiology and behavior are coordinated by the suprachiasmatic nucleus (SCN) in the hypothalamus. Within SCN neurons, various aspects of cell physiology exhibit circadian oscillations, including circadian clock gene expression, levels of intracellular Ca2+ ([Ca2+]i), and neuronal firing rate. [Ca2+]i oscillates in SCN neurons even in the absence of neuronal firing...
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In the mammalian suprachiasmatic nucleus (SCN), noisy cellular oscillators communicate within a neuronal network to generate precise system-wide circadian rhythms. Although the intracellular genetic oscillator and intercellular biochemical coupling mechanisms have been examined previously, the network topology driving synchronization of the SCN has not been elucidated. This network has been par...
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So what’s the fuss? In mammals, it is the site of an endogenous pacemaker that regulates 24 hour, circadian rhythmicity, synchronizing the phases and periods of a host of behavioral, physiological, and hormonal rhythms to the environmental light–dark cycle. The SCN also appears to function as a seasonal clock underlying the measurement of daylength. The SCN was first implicated as a master cloc...
متن کاملRhythmic properties of the hamster suprachiasmatic nucleus in vivo.
We recorded multiple unit neural activity [multiunit activity (MUA)] from inside and outside of the suprachiasmatic nucleus (SCN) in freely moving male golden hamsters housed in running-wheel cages under both light/dark cycles and constant darkness. The circadian period of MUA in the SCN matched the period of locomotor activity; it was approximately 24 hr in wild-type and 20 hr in homozygous ta...
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ژورنال
عنوان ژورنال: Annual Review of Physiology
سال: 2010
ISSN: 0066-4278,1545-1585
DOI: 10.1146/annurev-physiol-021909-135919